The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:wherein Z1, Z2, Z3, Z4, X, Y, R2, R3and R4are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.本發明係關於作為鈉通道抑制劑之化合物及其治療各種疾病狀態，包括心血管疾病及糖尿病之用途。在特定實施例中，該等化合物之結構由式I給出：其中Z1、Z2、Z3、Z4、X、Y、R2、R3及R4係如本文所述，本發明係關於製備及使用該等化合物之方法及含有該等化合物之醫藥組合物。
