A sampling system comprises a mailing package； a cell sampling device comprising a flexible shaft having a handle at one end, wherein the shaft is configured to allow an individual to self collect a cell sample from mucous tissue, and a sample collecting element removably connectable with the other end of the shaft and operable to collect a cell sample from mucous tissue of an individual； and a sealable unit, wherein the unit is configured to store the sample collecting element having a cell sample thereon configured to receive the remaining components of the system for delivery to a user.
