An ultrasound imaging system and method employs hardware and/or software to monitor values indicative of analog-to-digital converter (ADC) saturation for each channel as a function of depth. Any of a number of actions may be performed based on the monitored values. For example, analog amplification or TGC may be adjusted to enhance the use of a dynamic range of ADCs while reducing or eliminating ADC saturation. A TGC profile may be adjusted. An alert may be provided. A power consumption may be adjusted.