Vivek A. Kumar,Peter Nguyen,Biplab Sarkar,Sruti Rachapudi,Patricia Iglesias-Montoro
申请号：
US16442044
公开号：
US20190380957A1
申请日:
2019.06.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A mimic of an anti-angiogenic peptide is combined with a self-assembling peptide hydrogel to provide improved treatment for pathological neovascularization management. Pathological neovascularization may cause or worsen intraocular posterior segment diseases, such as diabetic retinopathy (DR) and wet age-related macular degeneration (wet AMD). The attachment of a therapeutic anti-angiogenic motif to a fibrillizing peptide backbone that undergoes nanofibrous self-assembly into an injectable hydrogel was found beneficial for the treatment of aberrant neovascularization. The peptide persists for extended periods in a target site for prolonging the therapeutic timeframe. This injectable hydrogel therapy may unlock potential clinical routes for treating many neovascular diseases.
