A medical composite material, a method for fabricating the same and applications thereof are disclosed, wherein the medical composite material includes an interface layer, a polymer layer and a metal layer. The interface layer has a first surface, a second surface opposite to the first surface and a plurality protrusion portions protruding outwards from the first surface, wherein each of the protrusion portions has an aspect ratio substantially ranging from 1 μm to 4000 μm. The polymer layer is conformally in contact with the first surface and the protrusion portions. The metal layer is in contact with the second surface.