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ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用
专利权人:
国立大学法人;東京大学
发明人:
片岡 一則,位高 啓史,西山 伸宏,福島 重人,張 祐銅,宮田 完二郎,中西 政崇,浅野 俊策,金山 直樹
申请号:
JP2007502678
公开号:
JP5061349B2
申请日:
2006.02.08
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
A composition for the delivery of nucleic acid to target cells or tissues, which comprises polycationically charged polymer as a carrier of nucleic acid is provided. Said polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula -NH-(CH 2 ) a -(NH(CH 2 ) 2 ) e -NH 2 (wherein a and e independently denote an integer of 1 to 5) which is connected to said main chain either directly or via a linker. This composition is low-toxic, and has a high efficiency in introducing nucleic acid into cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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