RANCATI, Fabio,RIZZI, Andrea,CARZANIGA, Laura,LINNEY, Ian,KNIGHT, Chris,SCHMIDT, Wolfgang
申请号：
PE0013682017
公开号：
PE13472017A1
申请日:
2016.02.10
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a compound of formula (i), where q is as shown in the figure, and Y1 or Y2 A1 and A2 are absent or are (C1 C12) alquileno (C3, C8) cicloalquileno, among others b is absent or is (C3 - cicloalquileno (C8) C3 - C8) heterocicloalquileno, among others c is absent or - or -, - C (o) -, Among others d is absent or is (C1 - alquileno (C12), C2 C12) alquenileno, among others n and s are 0, 1,2 or 3 and is absent or - O -, - S -, among others g is heteroarileno arylene or optionally substituted r1 is (ISBN cycloalkyl (C8), C3, C8) heterocicloalquilo, among others R2 is a group that contains N - such as nr3r4 R3 and R4 are H or alkyl (c1-c4), or R2 might be another.It is a selected compound: 2 - hydroxy - 2 - (3 - (5 - (((R) - 2-hydroxy-2 - (8 - hydroxy - 2 - oxo - 1.2 - dihidroquinolin - 5 - il) ethyl) amino) Pentyl) oxy) phenyl) - 2 - (1 phenylacetate bencilpiperidin - 4 - Methyl - il), among others. It also relates to a Pharmaceutical composition, a Composition and a device.Said Compound has Muscarinic receptor antagonist activity and beta2 adrenergic receptor agonist activity, being useful in the treatment of Lung diseases such as Asthma, chronic obstructive pulmonary disease (COPD), among others.Se refiere a un compuesto de formula (I), donde Q es como se muestra en la figura, Y es Y1 o Y2 A1 y A2 estan ausentes o son (C1-C12)alquileno, (C3-C8)cicloalquileno, entre otros B esta ausente o es (C3-C8)cicloalquileno (C3-C8)heterocicloalquileno, entre otros C esta ausente o es -O-, -C(O)-, entre otros D esta ausente o es (C1-C12)alquileno, (C2-C12)alquenileno, entre otros n y s son 0, 1, 2 o 3 E esta ausente o es -O-, -S-, entre otros G es arileno o heteroarileno, opcionalmente sustituido R1 es (C3-C8)cicloalquilo, (C3-C8)heterocicloalquilo, entre otros R2 es un grupo que contiene N tal como -NR3R4 R3 y R4 son H o (C1-C4)alquilo, o R2 puede ser otro grupo. Es un compuesto seleccionado: 2-hidroxi-2-(3-((5-(((R)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)et
