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Amorphous besifloxacin solid
专利权人:
Mohannad Shawer
发明人:
Mohannad Shawer,Eric Phillips,Harry M. King, Jr.
申请号:
US12956009
公开号:
US08518935B2
申请日:
2010.11.30
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Amorphous solid-state form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is characterized by at least one of: (a) an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 6.9-7.1, 9.4, 10.6-10.7, and 13.4-13.7°±0.2°, and a diffuse halo pattern at 11-30° and (b) a DSC (differential scanning calorimetry) melting peak at about 267-272° C. The amorphous solid is prepared by rapid precipitation from a saturated or supersaturated solution of besifloxacin free base in a solvent comprising at least benzyl alcohol.
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