THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;OCHSNER CLINIC FOUNDATION;NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人:
MATSUSHITA, OSAMU,GENSURE, ROBERT C.,SAKON, JOSHUA,PONNAPAKKAM, TULASI
申请号：
CA2930681
公开号：
CA2930681C
申请日:
2008.04.09
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
