HPRD - HEALTH PRODUCTS RESEARCH AND DEVELOPMENT LDA
发明人:
Rita Manuela PALMEIRA DE OLIVEIRA,Ana Cristina PALMEIRA DE OLIVEIRA
申请号：
US15521403
公开号：
US20170304411A1
申请日:
2015.10.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present disclosure relates to the field of therapeutics for skin and mucosal infections and refers to the use of bromelain either alone or with antimicrobial agents to inhibit, to reduce or to treat biofilms in infections derived from the presence of this pathogenicity mechanism. This application aims to use the enzymatic action of bromelain to destroy the biofilms and allow for the penetration of the antifungals therefore improving their action in the site of infection, treating and reducing symptoms.The present disclosure may be used in the pharmaceutical field for the treatment of infections, as creams, lotions, gels or vials for local application in the skin or mucosa.Formulations with the ability to maintain the stability of the enzyme and of the other active components were developed with good characteristics for skin or mucosal application, particularly in the vagina, promoting, in this way, the efficacy and acceptability of the final product.
