Han Sol Seo;Ye Rang Kim;Kyeong Yeol Seong;Dong Won Lee;Hyung Min Kim
发明人:
Dong Won Lee,Kyeong Yeol Seong,Han Sol Seo,Hyung Min Kim,Ye Rang Kim
申请号：
US13500326
公开号：
US08920793B2
申请日:
2012.02.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to the preparation of poly(amino oxalate) (PAOX) using oxalyl chloride, 1,4-cyclohexanedimethanol, and piperazinediethanol, the preparation of biodegradable polymer particles using the PAOX, and the use of PAOX particles as a drug delivery vehicle. The PAOX according to the present invention is a polymer that has three characteristics of biodegradability, biocompatibility, and cationic properties at the same time with appropriate hydrophobicity and thus can be prepared as particles that allow rapid drug release. Moreover, the particles improve the delivery efficiency of a drug into cells and thus can be efficiently used as a drug delivery vehicle for the treatment of acute inflammatory diseases such as acute liver failure and acute lung injury.
