Composition and method for muscle repair and regeneration

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专利权人:

THOMAS JEFFERSON UNIVERSITY

发明人:

IWAMOTO MASAHIRO,PACIFICI MAURIZIO

申请号：

NZ60754711

公开号：

NZ607547A

申请日:

2011.08.31

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Provided is the use of a retinoic acid receptor gamma (RAR&gamma；) agonist or pluripotent or multipotent stem cells pre-treated by contact with a RAR&gamma； agonist for muscle repair or regeneration. Examples of RAR&gamma； agonists include palovarotene (4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]-ethenyl]-benzoic acid), (4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid) (CD 1530), (6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid) (CD 437) and (3-Fluoro-4-[(R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetylamino]-benzoic acid) (BMS-270394).

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中国工程科技知识中心

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