A tissue acquisition and handling system includes a biopsy device, a tray, and a container. The biopsy device includes a needle and a tissue sample holder assembly. The needle is configured to acquire tissue samples and communicate tissue samples to the tissue sample holder assembly. The tray includes a plurality of strips. The tray is configured to be receiving within the tissue sample holder assembly of the biopsy device. The container includes a plurality of tray receiving portions. Each tray receiving portion includes a distal end, a proximal end, and a tray chamber, the tray chamber extends between the proximal end and the distal end. The tray chamber is configured to receive at least a portion of the tray through a tray opening of the proximal end.