Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient

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专利权人:

Boehringer Ingelheim International GmbH

发明人:

Albert Barta

申请号：

US15371252

公开号：

US10004743B2

申请日:

2016.12.07

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to a drying process of BIBW 2992 or the salts thereof, preferably the dimaleate salt, as well as of solid pharmaceutical formulations comprising BIBW2992 or a salt thereof, and to pharmaceutical compositions comprising BIBW 2992 or a salt thereof as the active product ingredient, characterized by a water activity of the formulation of not more than 0.20 or a water content (Karl-Fischer) of not more than 4.2%.

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