HURWITZ, Arthur A.;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;WATKINS, Stephanie K.
发明人:
HURWITZ, Arthur A.,WATKINS, Stephanie K.
申请号：
USUS2011/020315
公开号：
WO2011/085063A9
申请日:
2011.01.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides methods of enhancing an immune response to a cancer antigen in a mammal comprising inhibiting the activity of the foxo3a gene or gene product in dendritic cells in the mammal. The invention also provides methods of suppressing an immune response to an autoimmune disease antigen in a mammal comprising increasing the activity of the foxo3a gene or gene product in dendritic cells in the mammal. The invention also provides related methods of treating cancer and autoimmune diseases.
