ANALYSE DE RESEAUX DE SIGNALISATION IMMUNITAIRE POUR L'IDENTIFICATION DE CIBLES THERAPEUTIQUES DANS DES TROUBLES MEDICAUX CHRONIQUES COMPLEXES, IDENTIFICATION D'UNE POPULATION DE CELLULES TUEUSES NATURELLES EN TANT QUE CIBLE THERAPEUTIQUE POTENTIELLE POUR LE SYNDROME DE LA GUERRE DU GOLFE ET L'ENCEPHALO-MYELITE MYALGIQUE/LE SYNDROME DE LA FATIGUE CHRONIQUE
FLETCHER, MARY ANNE,BRODERICK, GORDON,KLIMAS, NANCY,BARNES, ZACHARY
申请号：
CA2954741
公开号：
CA2954741A1
申请日:
2014.10.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3-/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin- 15 (IL-15).
