The Board of Trustees of the Leland Stanford Junior University
发明人:
Ophir Vermesh,Sanjiv Sam Gambhir,Seung-min Park,Tianjia Jessie Ge,Amin Aalipour
申请号：
US15175959
公开号：
US20160354116A1
申请日:
2016.06.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A medical device and method for detection, retrieval or elimination of disease-associated toxins and biomarkers is provided. A plurality of magnets is arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached to each other, end-to-end, and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. The medical device is completely self-contained and does not require a bulky external field source able to maintain strong magnetic field gradients (100-10,000 T/m) along the wire, and at a radial distance (˜1 mm) to attract magnetic particles throughout the entire vein diameter at a range of physiologic velocities (1-10 cm/sec). This technology is a major step forward for the clinical relevance of CTC analysis to personalized medicine and introduces a powerful generalizable strategy for enrichment of other rare blood biomarkers.
