In one aspect, provided herein are whole spores engineered to capsulate a compound(s) or substance(s). In certain embodiments, the whole spore encapsulating the compound(s) or substance(s) is coated with or co-encapsulated with a hydrogel or other agent(s) to control the rate release of the compound(s) or substance(s) from the spore. In another aspect, provided herein are methods of producing whole spores encapsulating a compound(s) or substance(s). In another aspect, provided herein are formulations comprising either a whole spore, or a whole spore encapsulating a compound(s) or substance(s), and uses of those formulations.在一個態樣中，本文提供經工程化以包覆化合物或物質之完整孢子。在某些實施例中，該包覆化合物或物質之完整孢子係塗佈有或共包覆有水凝膠或其他試劑，以控制化合物或物質自孢子釋放之速率。在另一態樣中，本文提供製造包覆化合物或物質之完整孢子之方法。在另一態樣中，本文提供包含完整孢子或包覆化合物或物質之完整孢子之調配物及該等調配物之用途。
