Humanized anti-CD19 antibodies and their use in the treatment of cancer, transplantation and autoimmune diseases

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专利权人:

メディミューン，エルエルシー;メディミューン,エルエルシー

发明人:

ダムシュローダー，メリッサ,キーナー，ピーター,ウー，ヘレン,ダル’アクア，ウイリアム,ヘルブスト，ロナルド,コイル，アンソニー,ダムシュローダー,メリッサ,キーナー,ピーター,ウー,ヘレン,ダル’アクア,ウイリアム,ヘルブスト,ロナルド,コイル,アンソニー

申请号：

JP2009527592

公开号：

JP5401314B2

申请日:

2007.09.07

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention provides chimeric and humanized versions of anti-CD19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human CD19 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and disorders, such as, but not limited to, B cell malignancies, for the treatment and prevention of autoimmune disease, and for the treatment and prevention of graft-versus-host disease (GVHD), humoral rejection, and post-transplantation lymphoproliferative disorder in human transplant recipients.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/