System and methods for deriving gene signature biomarkers of response to PD-1 antagonists

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

Ayers, Mark D.,Loboda, Andrey,Lunceford, Jared K.,McClanahan, Terrill K.,Murphy, Eric E.,Nebozhyn, Michael

申请号：

AU2015360736

公开号：

AU2015360736A1

申请日:

2015.12.08

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

A gene expression platform, which is a combination of a set of genes that are correlated with response to a PD-1 antagonist in multiple tumor types and a normalization gene set, is disclosed. A method and system of using the gene expression platform to derive gene signature biomarkers of anti-tumor response to a PD-1 antagonist and to test patient samples for predictive gene signature biomarkers are also disclosed.

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