Compositions and methods for modulating AMPA receptor-mediated excitotoxicity

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专利权人:

CENTRE FOR ADDICTION AND MEDICAL HEALTH

发明人:

Fang Liu

申请号：

US14011434

公开号：

US09062285B2

申请日:

2013.08.27

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention provides AMPAR excitotoxicity mediating polypeptides comprising the GAPDH(2-2-1-1) (I221-E250)amino acid sequence (SEQ ID NO:2). Also disclosed are nucleotide sequences encoding the polypeptides, methods of inhibiting GAPDH association with the GluR2 subunit or p53. Methods of inhibiting AMPA receptor mediated excitotoxicity using the polypeptides and nucleic acids are also disclosed.

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