#$%^&*AU2017236019B220191219.pdf#####ABSTRACT Disclosed herein are polypeptides and fusion polypeptides having one or more of the activities of stimulating Tsp-I expression, activating p53, inhibiting angiogenesis, inhibiting tumor growth, inhibiting tumor invasiveness, and inhibiting tumor metastasis. Said polypeptides consist essentially of the amino acid sequence CDWLPK (SEQ ID NO: 3), DWLPK (SEQ ID NO: 4), or DWLP (SEQ ID NO: 5), or an amino acid substitution variant thereof, wherein the amino acid substitution is: a) Tyrosine (Y) for Tryptophan (W)； b) a conservative amino acid substitution for Leucine (L)； c) Arginine (R) for Lysine (K)； d) a Disomer of Aspartic Acid (D) for an L-isomer of Aspartic Acid (D) and/or a D-isomer of Leucine (L) for a L-isomer of Leucine (L)； e) a D-isomer of Tryptophan (W) for an L-isomer of Tryptophan (W) and/or a Disomer of Proline (P) for an L-isomer of Proline (P)； f) Alanine (A) or Glycine (G) for Leucine (L)； or combinations thereof.
