WINSTON WILLIAM M. JR.,MEETZE KRISTAN,WENG ZHIGANG,GYURIS JENO,CHEN TING,BAI AILIN,WEILER SOLLY
申请号：
NZ60397211
公开号：
NZ603972A
申请日:
2011.05.11
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is an isolated antibody that is capable of binding human FGFR2 comprising an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region comprising: - a CDRH1 comprising an amino acid sequence selected from the group consisting of SYWMH (SEQ ID NO: 5) and GYTFSSY (SEQ ID NO: 47) - a CDRH2 comprising the amino acid sequence of AIYPGNSDTDYSQKFQG (SEQ ID NO: 38) - a CDRH3 comprising the amino acid sequence of SKFDY (SEQ ID NO: 11) - a CDRL1 comprising the amino acid sequence of RASSSVNYMY (SEQ ID NO: 41) - a CDRL2 comprising the amino acid sequence of LTSNRAT (SEQ ID NO: 42) and - a CDRL3 comprising the amino acid sequence of QQWSSNPYT (SEQ ID NO: 14). Also disclosed is the use of said antibody in the treatment of cancer.
