Nathan W. Schmidt,Gerard C. L. Wong,Andrea Kasko,Stephanie Deshayes,Wujing Xian
申请号：
US15503673
公开号：
US20170348337A1
申请日:
2015.08.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Compositions and methods are disclosed that relate to aminoglycoside-linker-peptide (P-L-A) conjugates having unexpectedly advantageous dual-function bactericidal properties. Encompassed compounds are shown to be capable of energy independent bacterial plasma membrane disruption and to exhibit potent toxicity to bacteria including antibiotic-resistant bacteria. These and related embodiments will find uses for treating bacterial infections including overcoming antibiotic resistance.
