Massachusetts Institute of Technology;The Brigham and Women's Hospital, Inc.
发明人:
Carlo Giovanni Traverso,Robert S. Langer,Malvika Verma,Niclas Roxhed,Feyisope Eweje,Macy Castaneda
申请号：
US16427414
公开号：
US20190365418A1
申请日:
2019.05.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).
