QRXPHARMA LTD.;RICHARDS, Patricia, T.;STERN, Warren, C.
发明人:
STERN, Warren, C.,RICHARDS, Patricia, T.
申请号：
USUS2012/036441
公开号：
WO2012/151463A2
申请日:
2012.05.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods for detecting enhanced risk of opioid-induced respiratory dysfunction in patients with normal levels of oxygen saturation. The method may comprise: (1) assaying blood of the patient for a normal level of oxygen saturation； (2) measuring the patient's respiration rate at rest for a normal rate； and (3) correlating the normal level of oxygen saturation and the normal rate of respiration with enhanced risk of opioid-induced respiratory dysfunction if: (a) the patient is at an altitude of about 1000 feet above sea level or greater； or (b) the patient's oxygen saturation level is normal but no greater than about 95%； or (c) the patient received prior dosing with intravenous opioid and is converted to dosing with an oral opioid. The method may further comprise administering opioids to a patient after detecting whether there is an enhanced risk of opioid-induced respiratory dysfunction.
