PROBLEM TO BE SOLVED: To provide a means for the effective and safe prevention, recovery, improvement or deterioration-recurrence prevention of various kinds of inflammatory diseases caused by the PAF operating receptor bonding of PAF.SOLUTION: There are provided a biotinylated peptide compound which is produced by adding biotin to a peptide having an amino acid sequence of Tyr-Lys-Asp-Gly, Tyr-Lys-Asp-Lys-Glu or Tyr-Lys-Gly-Lys, and is bound to a platelet-activating factor (PAF) and lyso PAF to inhibit the PAF-operating receptor bonding of PAF and an anti-inflammatory disease agent containing the biotinylated peptide compound as an active ingredient.COPYRIGHT: (C)2013,JPO&INPIT【課題】PAFのPAF作動性受容体結合を原因とする各種の炎症性疾患に対する有効かつ安全な予防、回復、改善または悪化・再発予防のための手段を提供する。【解決手段】Tyr-Lys-Asp-Gly、Tyr-Lys-Asp-Lys-GluまたはTyr-Lys-Gly-Lysのアミノ酸配列を有するペプチドにビオチンが付加されており、生体内において血小板活性化因子(PAF)およびリゾPAFと結合してPAFのPAF作動性受容体結合を阻害するビオチニル化ペプチド化合物と、このビオチニル化ペプチド化合物を有効成分とする抗炎症剤。【選択図】なし
