Общество с ограниченной ответственностью "Озон" (RU)
发明人:
Алексенко Павел Владимирович (RU)
申请号：
RU2012141603/15
公开号：
RU2012141603A
申请日:
2012.09.28
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. dispersible tablet azithromycin preformed by compression of granules containing azithromycin in an amount of from 125 to 500 mg or a pharmaceutically acceptable salt thereof, microcrystalline cellulose and pregelatinized starch in a ratio of from 1.5: 1 to about 1:14, and desired additives introduced in granulation and powdering step, able to disperse in water within 3 minutes to form a dispersion consisting of particles smaller than 710 microns, wherein the tablet contains the said components in the following ratio, wt.%: 2. Dispersible tablet according to claim 1 comprising within the granules prozhelatinizirovanny starch in an amount of 5-15 wt.%. 3. Dispersible tablet according to claim 1 comprising within the granules prozhelatinizirovanny starch in an amount of 7-11 wt.%. 4. Dispersible tablet according to claim 1 comprising within the granules prozhelatinizirovanny starch in an amount of 10 wt.%. 5. Dispersible tablet according to claim 1 comprising within the granules of silicon dioxide colloid in an amount of 0.25-2.5 wt.%. 6. Dispersible tablet according to claim 1 comprising within the granules of silicon dioxide colloid in an amount of 1.5-2.0 wt.%. 7. Dispersible tablet according to claim 1 comprising within the granules of silicon dioxide colloid in an amount of 1.79 wt.%. 8. A process for preparing a dispersible tablet azithromycin, which comprises mixing the pharmaceutically active compound with targeted additions of water is added in an amount sufficient to moisten the dry mixture is granulated resulting wet mixture by mixing until granules are dried granules were mixed the granules with desired additives and compressed pellets molded tablets, components use according to claim 1, of which cellulose mikrokr1. Диспергируемая таблетка азитромицина, сформованная путем прессования из гранул, содержащих азитромицин в количестве от 125 до 500 мг или его фармацевтически приемлемую соль, микрокристаллическую целлюлозу и крахмал прежелатинизированный в соо
