MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE

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专利权人:

REGENERON PHARMACEUTICALS; INC.

发明人:

NITTOLI, Thomas,MARKOTAN, Thomas P.

申请号：

SG11201806322Q

公开号：

SG11201806322QA

申请日:

2017.01.24

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

International Patent Classification: CO7D 498/18 (2006.01) A61P 35/00 (2006.01) A61K 31/535 (2006.01) (21) International Application Number: PCT/US2017/014782 (22) International Filing Date: 24 January 2017 (24.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/286,858 25 January 2016 (25.01.2016) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US] 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). (72) (74) (81) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). arations under Rule 4.17: as to the identity of the inventor (Rule 4.17(1)) as to applicants entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicants entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Inventors: NITTOLI, Thomas c/o Regeneron Pharma- ceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). MARKOTAN, Thomas P. 518 Decl Washington Crossing Road, Newtown, Pennsylvania 19840 (US). Agents: OSTOMEL, Todd et al. Squire Patton Boggs (US) LLP, 620 Hansen way, Palo Alto, California 94304 (US). Designated Stat

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