PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS

• 收藏
• 分享

专利权人:

SIEGFRIED AG;CONTRAF-NICOTEX-TOBACCO GMBH

发明人:

WEBER, Beat,LOTHSCHÜTZ, Christian,PAN, Ben

申请号：

SG11202005639U

公开号：

SG11202005639UA

申请日:

2018.12.18

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one； (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine； (iii) reducing the myosmine to nornicotine using a reducing agent； and (iv) methylating the nornicotine to obtain the racemic nicotine.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/