Fundación Centro Nacional de Investigaciones Oncológicas Carlos III
发明人:
PASTOR FERNANDEZ, Joaquin,MARTINEZ GONZALEZ, Sonia,ALVAREZ ESCOBAR, Rosa María,RODRIGUEZ HERGUETA, Antonio,MARTIN HERNANDO, José Ignacio,RAMOS LIMA, Francisco
申请号：
ES11703723
公开号：
ES2627703T3
申请日:
2011.01.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I, ** Formula ** wherein: A1 represents N or C (R1)； A4 represents N or C (R1a)； A4a represents N or C (R1b)； where at least one of A4 and A4a does not represent N； A5 represents N or C (R2)； wherein when A4, A4a and A5 respectively represent C (R1a), C (R1b) and C (R2), then A1 does not represent N； each B1, B1a, B2, B2a, B3, B3a, B4 and B4a independently represent hydrogen or a substituent selected from halogen, -C (>； = Y) -R10a, -C (>； = Y) -OR10a, -C ( >； = Y) N (R10a) R11a, -S (O) 2N (R10a) R11a, C1-12 alkyl, heterocycloalkyl (whose last two groups are optionally substituted with one or more substituents selected from>； = O and E1), aryl and / or heteroaryl (whose last two groups are optionally substituted with one or more substituents selected from E2)； or any pair of substituents B1, B1a, B2, B2a, B3, B3a, B4 and B4a that are attached to the same carbon atom (i.e., B1 and B1a； B2 and B2a； B3 and B3a and / or B4 and B4a) they can form a group>； = O； or, any pair of substituents B1, B1a, B2, B2a, B3, B3a, B4 and B4a can be joined together to form another 3 to 12 member ring, which optionally contains (in addition to the morpholine ring atom (s)) one or more heteroatoms, whose ring optionally contains one or more double bonds, and whose ring is the same optionally substituted with one or more substituents selected from halogen,>； = O and C1-3 alkyl optionally substituted with one or more fluorine atoms ； R1 and R2 independently represent hydrogen or a substituent selected from halogen, -CN, -OR10b, -N (R10b) R11b, -C (O) N (R10b) R11b, C1-12 alkyl (e.g., C1- 6) and heterocycloalkyl, whose last two groups are optionally substituted with one or more substituents selected from E3 and>； = O； R1b (when present) represents: (i) C1-12 alkyl optionally substituted with one or more substituents selected from Q1a； (ii) heterocycloalkyl (linked through a carbon atom) optionally substituted with one or more substituents selected from>；
