INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo ~~~~ I D oimIE (43) International Publication Date 17 January 2019 (17.01.2019) (10) International Publication Number WO 2019/014100 Al WIPO I PCT Cmpd No. Total AUC Compd A 1232 Compd 1 1547.5 Figure 1B MICHAEL, James [GB/GB]； 11 Cherry Tree Lane, Ed- walton, Nottingham NG12 4AL (GB). CARRANCIO, So- raya [ES/US]； 5205 Fiore Terrace, Apt. B419, San Diego, CA 92122 (US). CATHERS, Brian E. [US/US]； 10040 Branford Road, San Diego, CA 92129 (US). CORREA, Matthew, D. [US/US]； 9025 Three Seasons Road, San Diego, CA 92126 (US). HANSEN, Joshua [US/US]； 5633 Bellevue Avenue, La Jolla, CA 92037 (US). HAVENS, Courtney, G. [US/US]； 3504 Felton Street, San Diego, CA 92104 (US). KERCHER, Timothy, S. [US/US]； 11283 Paul Barwick Court, San Diego, CA 92126 (US). LOPEZ- GIRONA, Antonia [US/US]； 8959 January Place, San Diego, CA 92122 (US). LU, Xiaoling [CN/US]； 3 Run- nymede Court, Whippany, NJ 07981 (US). MAN, Hon- Wah [US/US]； 27 Grant Way, Princeton, NJ 08540 (US). NAGY, Mark, A. [US/US]； 345 Willowspring Drive N., Encinitas, CA 92024 (US). NARLA, Rama, K. [US/US]； 5157 Great Meadow Drive, San Diego, CA 92130 (US). PICCOTTI, Joseph, R. [US/US]； 742 Rihely Place, Encinitas, CA 92024 (US). PIERCE, Daniel, W. [US/US]； 3406 Lodge Drive, Belmont, CA 94002 (US). TAVARES- GRECO, Paula, A. [BR/US]； 300 Parsippany Road, Par- sippany, NJ 07054 (US). WHITEFIELD, Brandon, W. [US/US]； 6406 Friars Road, #335, San Diego, CA 92108 (US). WONG, Lilly, L. [US/US]； 871 Viva Court, Solana (51) International Patent Classification: A61K 31/496 (2006.01) A61K 31/573 (2006.01) CO7D 241/02 (2006.01) A61P 35/00 (2006.01) A61K 38/05 (2006.01) (21) International Application Number: PCT/US2018/041230 (22) International Filing Date: 09 July 2018 (09.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/530,
