Quinoline compounds and pharmaceutical compositions, production methods and uses thereof

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专利权人:

上海医薬工業研究院

发明人:

チャイ チュンエン,チョウ ウェイチャン,ハオ チュン,シュ チェンホア,シュン ユチェン,シュン ミンユ,リャン チンニン

申请号：

JP2010549006

公开号：

JP5477974B2

申请日:

2009.04.29

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention discloses a quinoline compound represented by the formula A or pharmaceutically acceptable solvate, optical isomer or polymorph thereof, wherein X is S or O； M is H, Na + , NH4 + or Ca 2+ ； each of R 1 , R 2 and R 3 is independently H, halogen, the group represented by formula D or formula E； R is H, halogen, C1ˆ¼C4 alkyl or C1ˆ¼C4 alkoxy. The present invention also discloses its pharmaceutical composition and the preparation method thereof and application in manufacturing a medicament for inhibiting HMG-CoA reductase or for the treatment and prophylaxis of the diseases which can be treated effectively by inhibiting HMG-CoA reductase. The quinloline compound and pharmaceutical composition thereof of the present invention have an excellent lipid reduction effect in vivo and can be applied for treatment of a hyperlipidemia-related disease.

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