The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.本申請案係關於一種抗PD-L1抗體,編碼其之核酸,其治療性組合物,及其用於增進T細胞功能以調升細胞介導之免疫反應及治療T細胞功能障礙病症(包括感染,例如急性及慢性感染,及腫瘤免疫)之用途。