PROCESS FOR THE PREPARATION OF BENZOIMIDAZOL-2-YL PYRIMIDINE DERIVATIVES

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专利权人:

JANSSEN PHARMACEUTICA N.V.

发明人:

CESCO-CANCIAN, SERGIO,GRIMM, JEFFREY, S,MANI, NEELAKANDHA, S,MAPES, CHRISTOPHER, M,PALMER, DAVID, C,PIPPEL, DANIEL, J,XIAO, TONG,BROGGINI, DIEGO,LOCHNER, SUSANNE

申请号：

NZ59016909

公开号：

NZ590169A

申请日:

2009.06.29

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed herein is a process for the preparation of a compound of formula (I) and derivatives (I-A) and (I-B), wherein the substituents are as defined within the specification, comprising the steps of: reacting a compound of formula (V) with a reducing agent system； in a solvent； at a temperature in the range of from about 0°C to 25°C, to yield a compound of formula (VI)； followed by reacting a compound of formula (VI) with a compound of formula (VII) in the presence of an oxidizing agent system, in a solvent, at a temperature in the range of from about 20°C to 100°C to afford the compound of formula (I).

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