The present invention relates to the use of agomelatine, or N-¬2- (7-methoxy-1-phthyl) ethyl] acetamide, or its combination, in particular for the treatment of bipolar disorders, especially bipolar disorders. of types I and II, and more especially bipolar disorders of type I.The present invention relates to the use of agomelatine, or N-¬2-(7-methoxy-1-phthyl)ethylacetamide, on its own or in association, in obtaining medicaments intended for the treatment of bipolar disorders, especially bipolar disorders of types I and II, and more especially bipolar disorders of type I.