Disclosed are methods for treating Vascular Leak Syndrome. Further disclosedare methods for treating vascularleakage due to inflammatory diseases, inter alia, sepsis, lupus, irritablebowel disease. Yet further disclosed are methods fortreat-ing renal cell carcinoma and melanoma. Still further disclosed aremethods for reducing metastasis of malignant cells and/orpre-venting the proliferation of carcinoma cells via spreading due to vascularleakage.