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Crystalline forms of dihydropyrimidine derivatives
专利权人:
Sunshine Lake Pharma Co.; Ltd.
发明人:
ZHANG, Yingjun,REN, Qingyun,LIU, Xinchang,WANG, Chaolei,WANG, Tianming,GOLDMANN, Siegfried
申请号:
ES13841041
公开号:
ES2660642T3
申请日:
2013.09.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A crystalline form of the compound of Formula (I): ** (See formula) ** or a tautomer, wherein the crystalline form is Form B, which has a powder X-ray diffraction pattern (XRPD) comprising peaks expressed in grades 2θ at 6.68 ° ± 0.2 °, 13.39 ° ± 0.2 °, 19.65 ° ± 0.2 °, 20.26 ° ± 0.2 °, 22.45 ° ± 0.2 °, 24.80 ° ± 0.2 °, 25.01 ° ± 0.2 °, 26.19 ° ± 0.2 °, 26.61 ° ± 0.2 ° and 28.79 ° ± 0.2 °; or where the crystalline form is Form C, which has a powder X-ray diffraction pattern (XRPD) comprising peaks expressed in grades 2θ at 5.39 ° ± 0.2 °, 13.25 ° ± 0, 2nd, 16.00 ° ± 0.2 °, 17.27 ° ± 0.2 °, 21.33 ° ± 0.2 °, 21.92 ° ± 0.2 °, 22.53 ° ± 0, 2nd, 23.47 ° ± 0.2 °, 26.56 ° ± 0.2 °, 26.87 ° ± 0.2 °, 29.41 ° ± 0.2 ° and 32.22 ° ± 0, 2nd; or where the crystalline form is Form H, which has a powder X-ray diffraction pattern (XRPD) comprising peaks expressed in grades 2θ at 7.58 ° ± 0.2 °, 10.29 ° ± 0, 2nd, 12.00 ° ± 0.2 °, 19.07 ° ± 0.2 °, 19.93 ° ± 0.2 °, 20.78 ° ± 0.2 °, 21.33 ° ± 0, 2nd, 21.48 ° ± 0.2 °, 24.76 ° ± 0.2 °, 25.59 ° ± 0.2 °, 25.82 ° ± 0.2 °, 26.01 ° ± 0, 2nd and 26.58 ° ± 0.2 °; or where the crystalline form is Form I, which has a powder X-ray diffraction pattern (XRPD) comprising peaks expressed in grades 2θ at 9.41 ° ± 0.2 °, 17.59 ° ± 0, 2nd, 21.37 ° ± 0.2 °, 21.72 ° ± 0.2 °, 22.15 ° ± 0.2 °, 22.50 ° ± 0.2 °, 23.90 ° ± 0, 2nd, 24.59 ° ± 0.2 °, 24.99 ° ± 0.2 °, 26.32 ° ± 0.2 °, 27.09 ° ± 0.2 °, 29.68 ° ± 0, 2nd and 30.53 ° ± 0.2 °.Una forma cristalina del compuesto de la Formula (I): **(Ver fórmula)** o un tautomero, en donde la forma cristalina es la Forma B, que tiene un patron de difraccion de rayos X en polvo (XRPD) que comprende picos expresados en grados 2θ a 6,68° ± 0,2°, 13,39° ± 0,2°, 19,65° ± 0,2°, 20,26° ± 0,2°, 22,45° ± 0,2°, 24,80° ± 0,2°, 25,01° ± 0,2°, 26,19° ± 0,2°, 26,61° ± 0,2° y 28,79° ± 0,2°; o en donde la forma cristalina es la Forma C, que tiene un patron de difraccion de rayos X en polvo (XRPD) que comprende picos expresados en grados 2θ
来源网站:
中国工程科技知识中心
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