This invention relates to compositions for use in the treatment of diabetes, for example type-2 diabetes obesity and/or metabolic syndrome. Specifically, the invention relates to a composition for use in the treatment of diabetes, the composition comprising at least one of diindolylmethane indole-3-carbinol embelin [6]-gingerol and [6]-shogaol, or combinations each thereof. Also disclosed is use in the treatment of obesity and use in the treatment of metabolic syndrome.