A composite enterosorbent has a substrate in the form of a sorbent based on hydrogel of polymethylsiloxane. For the purpose of complex normalization of the intestinal microflora it further comprises a polysaccharide selected from the group including lactulose, inulin, fructooligosaccharides, alginic acid in the form of its pharmaceutically acceptable salts, acacia, pectin, chitosan, lignin. Respectively, the preparation comprises 0.1 to 10 parts by weight of polysaccharides per 1 part by weight of hydrogel of polymethylsiloxane.
