A medical device control handle has a first actuation member for actuating atleast onepuller wire in one manipulation of a medical device, including uni-directionaldeflection, if not apair of puller wires for bi-directional deflection of a catheter, and a secondactuation member foractuating an additional puller wire in another manipulation of the medicaldevice, wherein the firstand second actuation members have a common rotational axis without beingrotationally coupled.In one embodiment, a first actuation assembly has a first actuator, an armrotatable about an axis,and a first shaft. The first deflection actuator and the arm are rotationallycoupled by the rotationshaft, and the arm has at least one pulley that is engaged with a puller wire.The second wireactuation assembly has a second actuator and a second shaft having a spoolportion. Each actuationassembly has a friction-inducing element that provides friction torque betweencomponents of eachassembly such that the actuators are self-holding.