The present invention relates to a protein kinase inhibitor (I), various diseases, formula for use in treating cancer, central nervous system disorders or inflammation, especially. The invention is also directed to pharmaceutical compositions comprising the compounds of the invention and relates to the therapeutic uses thereof.本発明は、種々の疾病、特に癌、炎症または中枢神経系障害の治療に用いるための式(I)のタンパク質キナーゼ阻害剤に関する。本発明はまた、本発明の化合物を含む医薬組成物およびそれらの治療的使用に関する。