ITO YOSHIHIRO,伊藤 嘉浩,MIYATAKE HIDEYUKI,宮武 秀行,KUSHIDA TAKASHI,串田 尚
申请号：
JP2015165014
公开号：
JP2017043547A
申请日:
2015.08.24
申请国别(地区):
JP
年份:
2017
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a surface treatment agent for a member for biological transplantation that imparts property of binding to a metal material to a growth factor.SOLUTION: The present invention provides: a conjugate comprising at least one growth factor selected from a vascular endothelial cell growth factor (VEGF) and a bone morphogenetic protein (BMP), the factor having a molecular weight of 10,000 daltons or greater and a polypeptide including at least one amino acid residue selected from tyrosine derivatives and proline derivatives bound thereto an agent comprising the conjugate and a member for living donor transplantation. The present invention also provides a surface treating agent for the member for living donor transplantation. The surface treating agent comprises the conjugate in which the growth factor is at least one growth factor selected from a vascular endothelial cell growth factor (VEGF) and a bone morphogenetic protein (BMP). The tyrosine derivative is 3,4-dihydroxyphenylalanine (DOPA), the proline derivatives are 4-hydroxyproline and 3,4-dihydroxyproline, and the polypeptide includes a lysine residue.SELECTED DRAWING: Figure 8COPYRIGHT: (C)2017,JPO&INPIT【課題】成長因子に対して金属材料への結合性を付与する生体移植用部材の表面処理剤の提供。【解決手段】分子量が1万ダルトン以上の血管内皮細胞成長因子(VEGF)及び骨形成タンパク質(BMP)から選ばれる少なくとも一種の成長因子とそれに結合されたチロシン誘導体及びプロリン誘導体から選ばれる少なくとも一種のアミノ酸残基を含むポリペプチドとを含む結合体、並びに該結合体を含む剤及び生体移植用部材。前記成長因子が、血管内皮細胞成長因子(VEGF)及び骨形成タンパク質(BMP)から選ばれる少なくとも一種の成長因子であり、前記チロシン誘導体が3,4-ジヒドロキシフェニルアラニン(DOPA)であり、前記プロリン誘導体が4-ヒドロキシプロリン及び3,4-ジヒドロキシプロリンであり、前記ポリペプチドがリシン残基を含む、結合体であり、前記結合体を含む、生体移植用部材の表面処理剤。【選択図】図8
