HUANG, WEI TING,黄唯婷,黃唯婷,LEE, YI CHI,李翊绮,李翊綺,LIU, DEAN MO,刘典谟,劉典謨
申请号：
TW104124706
公开号：
TWI580432B
申请日:
2015.07.30
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention provides a one-pot synthesis method for preparing a drug composition encapsulating hydrophobic drug(s), hydrophilic drug(s), and modifying protein in the same environment, the method comprises steps of suspending an amphiphilic chitosan derivative, at least one hydrophobic drug(s), at least one hydrophilic drug(s) into a solvent to form a mixture in a condition that the pH value of the mixture is in a range without precipitating from the hydrophilicdrug(s) and the hydrophobic drug(s), wherein the amphiphilic chitosan derivative is modified by hydrophilic group(s) and hydrophobic group(s) and fter at least 12 hours, receiving the drug composition until pH value of the mixture is between pH 6 to 7. In the same reactor, the hydrophilic drug(s) and the hydrophobic drug (s) are encapsulated by one-pot synthesis and the protein could be modified on the amphiphilic chitosan nanoparticles. The present invention further provides a drug composition.一種藥物組成物之製法,係包括:將雙性幾丁聚醣衍生物、至少一種疏水性藥物、至少一種親水性藥物分散於溶劑中,以形成混合溶液,其中,該雙性幾丁聚醣衍生物係經複數親水基和複數疏水基改質,且調配該混合溶液的pH在該親水性藥物及該疏水性藥物不沉澱的範圍;以及攪拌該混合溶液至少12小時後,待該混合溶液的pH介於6至7時,收取該藥物組成物,俾藉由一鍋合成法同時包覆親水性及疏水性藥物,並且以一鍋合成法進行蛋白質修飾以提供一多功能性之藥物組成物。
