According to the present invention, an antibody against a Panton-Valentineleukocidin toxin contained in Staphylococcus aureus, a method and a kit fordetectingthe toxin with the use of the antibody, and a pharmaceutical compositioncontaining anantibody against a Panton-Valentine leukocidin toxin for treating PVLinfection causedby Staphylococcus aureus containing PVL are provided. Also, an antibody whichiscapable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukDand/or HlgB and an antibody which is capable of binding to Panton-ValentineleukocidinS and has no cross-reactivity to at least one of LukE, HlgC, and HlgA areprovided.