TRABANCO SUÁREZ Andrés Avelino,ROMBOUTS FREDERIK JAN RITA,TRESADERN GARY JOHN,VAN GOOL MICHIEL LUC MARIA,MACDONALD GREGOR JAMES,MARTINEZ LAMENCA CAROLINA,GIJSEN HENRICUS JACOBUS MARIA
申请号：
IN12/MUMNP/2013
公开号：
IN2013MN00012A
申请日:
2013.01.03
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to novel 5 6 dihydro 2H [1 4]oxazin 3 ylamine derivatives as inhibitors of beta secretase also known as beta site amyloid cleaving enzyme BACE BACE1 Asp2 or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds to processes for preparing such compounds and compositions and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta secretase is involved such as Alzheimer s disease (AD) mild cognitive impairment senility dementia dementia with Lewy bodies Down s syndrome dementia associated with stroke dementia associated with Parkinson s disease and dementia associated with beta amyloid.
