#$%^&*AU2010227087A920160218.pdf#####- 20 Abstract A system and method for monitoring cerebral compliance of a patient by placing a first pressure sensor in a first sub-dural location, preferably a sub5 meningeal location, within the brain of the patient and placing at least a second pressure sensor in a second sub-dural location, preferably a sub-meningeal location, within the brain which is different from the first location. At least one parameter from each of the signals derived from the pressure sensors is compared to estimate cerebral compliance for the patient. Alternatively, at least a single pressure sensor is 10 utilized with a generator of reference signals having at least two different frequencies. Preferably, any change in cerebral compliance is detected by determining a change in the compared parameter, and a perceptible indication is generated when cerebral compliance deviates beyond a pre-selected value. 15 07/10/10,va 18884 speci.doc.201/4 FIG. IA 10 22 26 24 \4 28 e------ -- 12, 18 -- 16 20 P 0 FIG. 1B 36 32 40382/4 70, p SC 8 60 C050 D 56 64 - M G w 4 6~ G FIG. 2 v~ B P 52 FIG. 3A FIG. 4A 82 102 ..- 106 86-- 100 80 104 L 84 109 108 FIG. 3B FIG. 4B 92 -96 126 93 94 120 -1 124 97 95 90 993/4 DATA ANALYSIS 160 PROCESS 162 DATA ARRAY WAVEFORM FEATURE DETECTION From (Peaks, First Derivative, Zero 168 SENSOR 1 Crossings) 164 DATA ARRAY WAVEFORM FEATURE DETECTION 170 From (Peaks, First Derivative, Zero SENSOR 2 Crossings) 0 : FIG n DATA ARRAY WAVEFORM FEATURE DETECTION From (Peaks, First Derivative, Zero SENSOR n Crossings) 172 166 COMPARE FEATURES FROM ALL WAVEFORMS and PERFORM CROSS 174 CORRELATION ANALYSIS ANALYZE PHASE DIFFERENCE, TIME LAG BETWEEN 176 WAVEFORMS and/or AMPLITUDE DIFFERENCES ISO DISPLAY CALCULATE COMPLIANCE COMPLIANCE VALUE and 178 WAVEFORM
