PROBLEM TO BE SOLVED: To provide a slow-release cilostazol tablet which is a pharmacologically active component efficacious in the suppression of blood platelet aggregation and the promotion of vascular relaxation by inhibiting phosphodiesterase types.SOLUTION: The present invention provides a slow-release cilostazol tablet of which the elution time is extended such that it can be taken once a day for expediency of drug-taking, and which minimizes the occurrence of headache which is a side effect during the taking of cilostazol preparations of the prior art and therefore improves the convenience of drug-taking for women, the elderly and children. The present invention also provides a slow-release cilostazol tablet which exhibits a stable elution pattern without any variation in the percentage eluted depending on the pH in the stomach in addition to an effect whereby release of the drug is delayed, by using a mixture of hydroxypropyl methyl cellulose and a carbomer as a release-controlling polymer.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】ホスホジエステラーゼタイプを阻害することで、血小板凝集を抑制して血管の弛緩を促進する効能がある、薬理学的有効成分であるシルロスタゾール徐放錠の提供。【解決手段】服用の便利性のために1日1回服用が可能に溶出時間を延長し、既存のシルロスタゾール製剤の服用時の副作用である頭痛の発現を最小化することにより、女性や老人、児童の服用便宜性を向上させたシルロスタゾール徐放錠。また、ヒドロキシプロピルメチルセルロースとカルボマーの混合物を放出制御用高分子で使用することにより、薬物の放出を遅延させる効果と共に、胃腸でのpHによる溶出率の変化なしに一定な溶出パターンを示すシルロスタゾール徐放錠。【選択図】図1
