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SYSTÈMES ET MÉTHODES POUR L'EXPRESSION D'ACIDES NUCLÉIQUES IN VIVO
专利权人:
Dnarx
发明人:
申请号:
EP16847422.9
公开号:
EP3349730A4
申请日:
2016.09.16
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention provides compositions, systems, kits, and methods for generating expression of one or more proteins and/or biologically active nucleic acid molecules in a subject (e.g., at therapeutic levels for extended periods required to produce therapeutic effects). In certain embodiments, systems and kits are provided that comprise a first composition comprising a first amount of polycationic structures, and a second composition comprising a therapeutically effective amount of expression vectors (e.g., non-viral expression vectors not associated with liposomes) that are CpG-free or CpG-reduced, where the expression vectors comprise a first nucleic acid sequence encoding: i) a first therapeutic protein or proteins, and/or ii) a first biologically active nucleic acid molecule or molecules.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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