SCHTEINGART, CLAUDIO D.,MENZAGHI, FREDERIQUE,JIANG, GUANGCHENG,ALEXANDER, ROBERTA VEZZA,SUEIRAS-DIAZ, JAVIER,SPENCER, ROBERT H.,CHALMERS, DEREK T.,LUO, ZHIYONG
申请号：
DK07870877
公开号：
DK2064228T3
申请日:
2007.11.12
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
The invention relates to synthetic tetrapeptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. An exemplary synthetic tetrapeptide amide of the invention is D-Phe-D-Phe-D-Leu-(&egr；-Me) D-Lys-[4-Amidinohomopiperazine amide]: Pharmaceutical compositions containing these compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Inflammation associated with conditions such as IBD and IBS, ocular and otic inflammation, other disorders and conditions such as pruritis, edema, hyponatremia, hypokalemia, ileus, tussis and glaucoma are treatable or preventable with the pharmaceutical compositions of the invention.
